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Advancing the science of drug innovation
Successful drug innovation grows from a deep appreciation of disease pathophysiology and ingenuity in fine-tuning the pharmacologic properties of promising disease-modifying agents.
Nektar is the global leader in polymer chemistry a powerful approach to drug design that focuses on creating new molecular entities with optimized drug pharmacology. Our success is rooted in two key strategies. The first is targeting well-characterized biomolecular pathways considered likely to yield significant therapeutic benefits. And the second is exploiting the structural malleability of polymers key chemical building blocks that provide a near-limitless toolbox with which to customize the behavior of a new molecule.
Defining the science of polymer conjugation
We call our approach to new drug development "smart pharmacology."
Our chemistry is being used to control pharmacokinetics, biodistribution, receptor selectivity, and other important properties with high precision. Simply put: smart pharmacology hits the right target in the right place in the body at the right time.
Nektar chemists and molecular engineers shape the behavior of polymer drug conjugates by carefully selecting the architecture, composition, and size of the polymer, and by identifying the right location and chemistry of the linker molecules that bind it to the active agent. The polymer component within the new molecule influences the PK, biodistribution and selectivity of the composite molecule, without compromising the biological action on the target receptors.
With our proprietary platform, a broad range of valuable functional attributes become accessible to new drugs. For example, we have developed methods to:
Click above to explore a few of the clinically important drug properties made possible by our expertise in advanced polymer chemistry.