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Here you will find information about our products and technologies, including articles by our scientists that have appeared in the world’s leading scientific publications. Also included are presentations given by our scientists at professional meetings and conferences.

Articles by our scientists have appeared in many of the world's leading scientific publications. Our scientists also are regularly invited to present at scientific meetings and conferences.



Pulmonary Publications
Year: 2002
Author(s)
Title
Publication
Dickson, E.W., Heard, S.O., Tarara, T.E., Weers, J.G., Brueggemann, B.A., Doern, G.V. Liquid ventilation with perflubron in the treatment of rats with pneumococcal pneumonia. Critical Care Medicine 2002, 30: 393-395.
Duddu, S.P, Sisk, S.A., Walter, Y.H., Tarara, T.E., Trimble, K.R., Clark, A.R., Eldon, M.A., Elton, R.C., Pickford, M., Hirst, P.H., Newman, S.P., Weers, J.G. Improved lung delivery from a passive dry powder inhaler using an engineered PulmoSphere powder.

Read article (.pdf, 1MB)		 Pharmaceutical Research 2002, 19(5): 689-695.
Hirst, P.H., Pitcairn, G.R., Weers, J.G., Tarara, T.E., Clark, A.R., Luis A. Dellamary, L.A., Hall, G., Shorr, J., Newman, S.P. In vivo lung deposition of hollow porous particles from a pressurized meter dose inhaler.

Read article (.pdf, 1MB)		 Pharmaceutical Research 2002, 19(3): 258-264.
Newhouse, M.T., Hirst, P.H., Duddu, S.P., Walter, Y.H., Tarara, T.E., Clark, A.R, Weers, J.G. Inhalation of a dry powder tobramycin PulmoSphere formulation in healthy volunteers. Chest, In press.


Year: 2001
Author(s)
Title
Publication
Bot, A.I., Smith, D.J., Bot, S., Dellamary, L., Tarara, T.E., Phillips, W., Weers, J.G., Woods, C.M. Receptor-mediated targeting of spray-dried lipid particles coformulated with immunoglobulin and loaded with a prototype vaccine. Pharmaceutical Research 2001, 18: 971-979.
Clark, A. Developments in inhaleable drug delivery. Life Science Today 2001 (April).
Newhouse, M., Corkery, K. Aerosols for systemic delivery of macromolecules. Respiratory Care Clinics of North America 2001 (June), 7(2): 261-275.
Smith, D.J., Gambone, L.M., Tarara, T., Meays, D.R., Dellamary, L.A., Woods, C.M., Weers, J. Liquid dose pulmonary instillation of gentamicin PulmoSpheres formulations: tissue distribution and pharmacokinetics in rabbits. Pharmaceutical Research 2001, 18: 1556-1561.


Year: 2000
Author(s)
Title
Publication
Bot, A., Tarara, T., Smith, D., Bot, S., Woods, C., Weers, J. Novel lipid based hollow-porous microparticles as a platform for immunoglobin delivery to the respiratory tract. Pharmaceutical Research 2000, 17(3): 275-283.
Dellamary, L., Tarara, T., Weers, J., et al Hollow porous particles in metered dose inhalers. Pharmaceutical Research 2000, 17(2): 168-174.
Tarara, T., Weers, J., Dellamary, L. Engineered powders for inhalation. Respiratory Drug Delivery VII Conference Proceedings 2000, Interpharm Press Inc., USA, pp. 413-415.
Weers, J.G. Dispersible powders for inhalation applications. Innovations in Pharmaceutical Technology 2000, 1(7): 111-116.
Weers, J., Tarara, T., Gill, H., English, B., Dellamary, L. Homodispersion technology for HFA suspensions: Particle engineering to reduce dosing variance. Respiratory Drug Delivery VII Conference Proceedings 2000, Interpharm Press Inc., USA, pp. 91-97.


Year: 1999 and Earlier
Author(s)
Title
Publication
Byron, P.R., Patton, J.S. Drug delivery via the respiratory tract. Journal of Aerosol Medicine 1994, 7: 49-75.
Chess, R. Economics of drug delivery. Pharmaceutical Research 1998, 15(2): 172-174.
Eljamal, M., Nagarajan, S., Patton, J.S. In situ and in vivo methods for pulmonary delivery. Models for Assessing Drug Absorption and Metabolism, Plenum Press, New York, 1996.
Patton, J.S. Deep-lung delivery of therapeutic proteins. Chemtech 1997, 27(12): 34-38.
Patton, J. S., Bukar, J., Nagarajan, S. Inhaled insulin. Advanced Drug Delivery Reviews 1999, 35: 235-247.
Patton, J.S. Mechanisms of macromolecule absorption by the lungs. Advanced Drug Delivery Reviews 1996, 19: 3-36.
Patton, J.S., Platz, R.M. Aerosol insulin – A brief review. Respiratory Drug Delivery IV Conference Proceedings 1994, Interpharm Press Inc., USA, pp. 65-74.
Patton, J.S., Platz, R.M. Pulmonary delivery of peptides and proteins for systemic action. Advanced Drug Delivery Reviews 1992, 8: 179-228.
Patton, J.S., McCabe, J.G., Hansen, S.E., Daugherty, A.L. Absorption of human growth hormone from the rat lung. Biotechnology Therapeutics 1989-1990, 1(3): 213-228.
Patton, J.S., Trinchero, P., Platz, R.M. Bioavailability of pulmonary delivery peptides and proteins: Alpha-interferon, calcitonins and parathyroid hormone. Journal of Controlled Release 1994, 28: 79-85.
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Other Pulmonary Publications of Interest
Author(s)
Title
Publication
Year: 2002        
Wang, L., Bot, S., Smith, D., Guo, G.R., Phillips, B., Dellamary, L., Bot, A. Basic immunological properties of spray-dried lipid microparticles developed for nasal and systemic administration of vaccines. STP Pharma Sci 2002, 12: 53-61.
 
Wang, L., Smith, D., Bot, S., Dellamary, L.A., Bloom, A., Bot, A. A synthetic dsRNA motif encompassing naturally occurring nucleotides has optimal effect on adaptive immunity. Journal of Clinical Investigation, In press.
 

Year: 2001		        
Cefalu, W.T., Skyler, J.S., et al Inhaled human insulin treatment in patients with type 2 diabetes mellitus. Annals of Internal Medicine 2001, 134(3): 203-207: 6.
 
Gerber, R.A., Gelfand, R.A., et al Treatment satisfaction with inhaled insulin in patients with type 1 diabetes. Diabetes Care 2001, 24(9): 1556-1559.
Skyler, J.S., Cefalu, W.T., et al Efficacy of inhaled human insulin in type 1 diabetes mellitus: a randomized proof-of-concept study. The Lancet 2001, 357(9253): 331-335: 3.

Year: 2000		      
Bot, A., Smith, D., Tarara, T., Harders, S., Bot, S., Langsetmo, I., Woods, C., Weers, J. Vaccination by antigen delivery to airway antigen presenting cells via engineered, lipid-based microparticles. Respiratory Drug Delivery VII Conference Proceedings 2000, Interpharm Press Inc., USA, pp. 327-328.
Year: 1999 and Earlier
Adjei, A., Gupta, P. Pulmonary delivery of therapeutic peptides and proteins. Journal of Controlled Release 1994, 29: 361-373.
Adjei, A.L., Carrigan, P.J. Pulmonary bioavailability of LH-RH analogs: Some biopharmaceutical guidelines. Journal of Biopharmaceutical Sciences 1992, 3(1/2): 247-254.
Colthorpe, P., Farr, S.J., Sith, I.J., Wyatt, D., Taylor, G. The influence of regional deposition on the pharmacokinetics of pulmonary-delivered human growth-hormone in rabbits. Pharmaceutical Research 1995, 12: 356-359.
Colthorpe, P., Farr, S.J., Taylor, G., Smith I.J., Wyatt, D. The pharmacokinetics of pulmonary-delivered insulin: A comparison of intratracheal and aerosol administration to the rabbit. Pharmaceutical Research 1992, 9: 764-768.
Edgington, S.M. The anatomy of access: Peptide drug delivery. Biotechnology 1991, 9: 1327-1331.
Franks, F. Thermomechanical properties of amorphous saccharides: Their role in enhancing pharmaceutical product stability. Biotechnology and Genetic Engineering Reviews 1999, 16: 281-292.
Franks, F. Long-term stabilization of biologics. Bio/Technology 1994, 12: 253-256.
Hastings, R.H., Grady, M., Sakuma, T., Matthay, M.A. Clearance of different-sized proteins from the alveolar space in humans and rabbits. Journal of Applied Physiology 1992, 73: 1310-1416.
Hubbard, R.C., Brantly, M.L., Sellers, S.E., Mitchell, M.E., Crystal, R.G. Anti-neutrophil-elastase defenses of the lower respiratory tract in alpha1-antitrypsin deficiency directly augmented with an aerosol of alpha1-antitrypsin. Annals of Internal Medicine 1989, 111: 206-221.
Kim, K.J., Matsukawa, Y., Lee, V.H.L., Crandall, E.D. Characteristics of albumin absorption across rat alveolar epithelial cell monolayers. Federation of American Societies for Experimental Biology Journal 1995, 9: A569 (abstract).
Kobayashi, S., Kondo, S., Juni, K. Permeability of peptides and proteins in human cultured alveolar A549 cell monolayer. Pharmaceutical Research 1995, 12: 1115-1119.
Laube, B. L., Georgopoulos, A., Adams, G.K. Preliminary study of the efficacy of insulin aerosol delivered by oral inhalation in diabetic patient. Journal of American Medical Association 1993, 269(16): 2106-2109.
Martin, R. J., Boguniewicz, M., Henson, J.E., Celniker, A.C., Williams, M., Giorno, R.C., Leung, D.Y. The effects of inhaled interferon gamma in normal human airways. American Review of Respiratory Disease 1993, 148 (6 pt 1): 1677-1682.
Matsukawa, Y., Kim, K.J., Yamahara, H., Lee, V.H.L., Crandall, E.D. Transport of horseradish peroxidase and dextrans across alveolar epithelial barrier. American Journal of Respiratory and Critical Care Medicine 1994, 149: A63.
Niven, R.W. Delivery of biotherapeutics by inhalation of aerosol. Critical Reviews in Therapeutic Drug Carrier Systems 1995, 12 (2 & 3): 151-231.
Niven, R.W., F.D., Cribbs, J.M. Pulmonary absorption of recombinant methionyl human granulocyte colony stimulation factor (r-huG-CSF) after intratracheal instillation in the hamster. Pharmaceutical Research 1993, 10: 1604-10.
Niven, R.W., Lott, F.D., Ip, A.Y., Cribbs, J.M. Pulmonary delivery of powders and solutions containing granulocyte colony-stimulating factor (rhG-CSF) to the rabbit. Pharmaceutical Research 1993, 11: 1101-1109.
Niven, R.W., Whitcomb, K.L., Shaner, L., Ip, A.Y., Kinstler, O.B. The pulmonary absorption of aerosolized and intratracheally instilled rhG-CSF and monoPEGylated rhG-CSF. Pharmaceutical Research 1995, 12: 1343-1349.
Niven, R.W., Whitcomb, K.L., Woodward, M., Liu, J., Jornacion, C. Systemic absorption and activity of recombinant consensus interferons after intratracheal instillation and aerosol administration. Pharmaceutical Research 1995, 12:1889-1895.
Pinski, J.T., Yano, K., Groot, K., Zsigo, J., Rekasa, Z., Comaru-Schally, A.M., Schally, A.V. Comparison of GH-stimulation by GH-RH (1-29) NH2 and an Agmatine GH-RH analog, after intravenous, subcutaneous and intranasal administration and after pulmonary inhalation in rats. International Journal of Peptide and Protein Review 1993, 41: 246-249.
Smith, P.L., Marcello, J., Chiossone, D.C., Orner, D., Hidalgo, I.J. Absorption of an RGD peptide (SK&F 106760) following intratracheal administration in rats. International Journal of Pharmaceutics 1994, 106: 95-101.
Smith, P.L., Yeulet, S.E., Citerone, D.R., Darke, F., Cook, M., Wall, D.A., Marcello, J. SK&F 110679: Comparison of absorption following oral or respiratory administration. Journal of Controlled Release 1994, 28: 67-77.
Wallace, B. M., Lasker, J.S. Stand and deliver: Getting peptide drugs into the body. Science 1993, 260: 912-913.
Yamahara, H., Lee, V.H.L., Kim, K.J. Horseradish peroxidase fluxes across alveolar epithelial cell monolayers. Pharmaceutical Research 1994, 10: S87 (abstract).
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Pulmonary Meeting Abstracts and Posters
Author(s)
Title
Meeting

Year: 2003
Clark, A.R., Chambers, C.B., Muir, D., Paboojian, S., Schuler, C., Newhouse, M.T. Deposition and Clearance of Coarse Bolus Aerosols: Effect of Biphasic Inhalation.

View poster (.pdf, 1MB)		 14th Congress of the International Society for Aerosols in Medicine, Baltimore, MD, June 2003.
   
Leach, C.L., Patton, J.S., Perkins, K.M., Kuo, M.C., Bueche, B., Guo, L., Bentley, M. Dry Powder Formulation of Inhaled PEG-Insulin Yields Prolonged Systemic Activity in Dogs.

View poster (.pdf, 1MB)		 American Diabetes Association 63rd Scientific Sessions, New Orleans, LA, June 2003.
   
Lechuga-Ballesteros, D., Stults, C.L.M., Vehring, R., Kuo, M.C. The Use of a Novel Excipient to Enable the Preparation of Stable and Dispersible Dry-Powder Aerosol Formulations by Spray Drying.

View poster (.pdf, 1MB)		 30th Annual Meeting of the Controlled Release Society, Glasgow, Scotland, July 2003.
Schiavone, H., Wist, A., Tzannis, S.T. Formulation Feasibility of Drug-Loaded PLGA Microspheres for Pulmonary Delivery.

View poster (.pdf, 1MB)		 14th Congress of the International Society for Aerosols in Medicine, Baltimore, MD, June 2003.
   

Year: 2002
Chan, H-K., Lechuga-Ballesteros, D., Feeley, J.C., Foss, W., Miller, D.P., Tep, V., Vehring, R., Clark, A.R. The effect of bulk and surface properties on the aerosol performance of dry powders for inhalation.

View poster (.pdf, 2MB)		 American Association of Pharmaceutical Scientists Annual Meeting, Toronto, Canada, November 2002.
   
   
Kuo, M-C., Tep, V., Gordon, M., Schiavone, H., Charan, C., Lechuga-Ballesteros, D. Preparation of stable and dispersible dry powder aerosol formulations by spray drying.

View poster (.pdf, 3MB)		 American Association of Pharmaceutical Scientists Annual Meeting, Toronto, Canada, November 2002.
Kuo, M-C., Tep, V., Lechuga-Ballesteros, D., Lalor, C., Yang, B., Kadrichu, N., Clark, A. Effect of hygroscopic growth inhibitors on dry powder aerosol performances and bioavailability.

View poster (.pdf, 1MB)		 American Association of Pharmaceutical Scientists Annual Meeting, Toronto, Canada, November 2002.
   
Leach, C.L., Patton, J.S., Perkins, K.M., Kuo, M., Roberts, M.J., Guo, M., Michael, B. PEG-insulin delivered by the pulmonary route provides prolonged systemic activity compared with insulin alone.

View poster (.pdf, 1MB)		 American Association of Pharmaceutical Scientists Annual Meeting, Toronto, Canada, November 2002.
   
Miller, D.P., Lechuga-Ballesteros, D., Williams, L., Tan, T., Kanda, J., Foss, W., Walton, O., Mandel, A., Cai, X. Dispersibility of spray-dried raffinose: Effects of particle size and relative humidity.

View poster (.pdf, 1MB)		 American Association of Pharmaceutical Scientists Annual Meeting, Toronto, Canada, November 2002.
Schiavone, H., Dani, B., Wist, A., Tzannis, S.T. Effect of freeze drying conditions on the aerosol performance of PLGA microspheres.

View poster (.pdf, 1MB)		 American Association of Pharmaceutical Scientists Annual Meeting, Toronto, Canada, November 2002.
   
Yang, B., Lesikar, D., Tan, M.M., Ramachandran, S., Stevenson, C.L. Formulation of human growth hormone for pulmonary delivery.

View poster (.pdf, 3MB)		 American Association of Pharmaceutical Scientists Annual Meeting, Toronto, Canada, November 2002.
   
Zhang, J., Miller, D., Tan, T., Hastedt, J., Lechuga-Ballesteros, D. Characterization of water vapor interactions with binary amorphous mixtures.

View poster (.pdf, 1MB)		 American Association of Pharmaceutical Scientists Annual Meeting, Toronto, Canada, November 2002.
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PEGylation

PEGylation Publications


Year: 2002
Author(s)
Title
Publication
Chapman, A.P. PEGylated antibodies and antibody fragments for improved therapy: A review.

Read article (.pdf, 1MB)		 Advanced Drug Delivery Review 2002, 54: 531-545.
Reddy, K.R., Modi, M.W., Pedder, S. Use of peginterferon alfa-2a (40KD) (Pegasys) for the treatment of hepatitis C.

Read article (.pdf, 1MB)		 Advanced Drug Delivery Review 2002, 54: 571-586.
Roberts, M.J., Bentley, M.D., Harris, J.M. Chemistry for peptide and protein PEGylation.

Read article (.pdf, 1MB)		 Advanced Drug Delivery Review 2002, 54: 459-476.
Wang, Y-S., Youngster, S., Grace, M., Bausch, J., Bordens, R., Wyss, D.F. Structural and biological characterization of PEGylated recombinant interferon alpha-2b and its therapeutic implications.

Read article (.pdf, 1MB)		 Advanced Drug Delivery Review 2002, 54: 547-570.


Year: 2001
Author(s)
Title
Publication
Reddy, K., Wright, T.L., Pockros, P.J., Shiffman, M., Everson, G., Reindollar, R., Fired, M.W., Purdum, P.P., Jensen, D., Smith, C., Lee, W.M., Boyer, T.D., Lin, A., Pedder, S., DePamphilis, J. Efficacy and safety of pegylated (40 KD) interferon alfa-2a compared with interferon alfa-2a in noncirrhotic patients with chronic hepatitis C. Hepatology 2001, 33: 433-438.


Year: 2000
Author(s)
Title
Publication
Heathcote, E.J., Shiffman, M.L., Cooksley, W.G.E., Dusheiko, G.M., Lee, S.S., Balart, L., Reindollar, R., Reddy, R.K., Wright, T.L., Lin, A., Hoffman, J., DePamphilis, J. Peginterferon alfa-2a in patients with chronic hepatitis C and cirrhosis. New England Journal of Medicine 2000, 343: 1673-1680.
Zeuzem, S., Feinman, V.S., Rasenack, J., Heathcote, E.J., Lai, M.-Y., Gane, E., O’Grady, J., Reichen, J., Diago, M., Lin, A., Hoffman, J., Brunda, M.J. Peginterferon alfa-2a in patients with chronic hepatitis C. New England Journal of Medicine 2000, 343: 1666-1672.


Year: 1999 and Earlier
Author(s)
Title
Publication
Algranati, N.E., Sy, S., Modi, M. A branched methoxy 40 kDa polyethylene glycol (PEG) moiety optimizes the pharmacokinetics (PK) of peginterferon alfa-2a (PEG-IFN) and may explain its enhanced efficacy in chronic hepatitis C (CHC). Hepatology 1999, 30: Suppl: 109.
Harris, J.M. Polyethylene Glycol Chemistry. Biotechnical and Biomedical Applications. Plenum, New York, 1992.
Harris, J.M., Zalipsky, S. Chemistry and Biological Applications of Polyethylene Glycol. ACS Books, Washington, D.C., 1997.
Neiforth, K.A., Nadeau, R., Patel, I.H., Mould, D. Use of an indirect pharmacodynamic stimulation model of MX protein induction to compare in vivo activity of interferon alfa-2a and a polyethylene glycol-modified derivative in healthy subjects. Clinical Pharmacology and Therapeutics 1996, 59: 636-646.
Will, R.J. Clinical pharmacokinetics of interferons. Clinical Pharmacokinetics 1990, 19: 390-399.



PEGylation Meeting Abstracts and Posters
Author(s)
Title
Meeting


Year: 2003
Green, M.E., Roberts, M., Goodin, R., Novak, M., Boyd, M., Mori, T., O'Keefe, B. Site-Specific Modification of a Mutant Cyanovirin-N with a Large Polyethylene Glycol Moiety Yields a Potent Anti-HIV Agent with Reduced Immunogenicity and Toxicity in Mice.

View poster (.pdf, 1MB)		 30th Annual Meeting of the Controlled Release Society, Glasgow, Scotland, July 2003.
Leach, C.L., Patton, J.S., Perkins, K.M., Kuo, M.C., Bueche, B., Guo, L., Bentley, M. Dry Powder Formulation of Inhaled PEG-Insulin Yields Prolonged Systemic Activity in Dogs.

View poster (.pdf, 1MB)		 American Diabetes Association 63rd Scientific Sessions, New Orleans, LA, June 2003.
Zhao, X., Allums, S., Battle, W., Bentley, M., Comeaux, W., Viegas, T., Yan, J. Synthesizing Oligomers of Poloxamer 407 as Degradable Thermal-Sensitive Depot Materials for Sustained Drug Release.

View poster (.pdf, 1MB)		 30th Annual Meeting of the Controlled Release Society, Glasgow, Scotland, July 2003.


Year: 2002
Leach, C.L., Patton, J.S., Perkins, K.M., Kuo, M., Roberts, M.J., Guo, M., Michael, B. PEG-insulin delivered by the pulmonary route provides prolonged systemic activity compared with insulin alone.

View poster (.pdf, 1MB)		 American Association of Pharmaceutical Scientists Annual Meeting, Toronto, Canada, November 2002.
Pedder, S. Clinical implications of the PEGylation of IFN-alfa-2a.

Read abstract (.pdf, 1MB)		 American Association of Pharmaceutical Scientists Annual Meeting, Toronto, Canada, November 2002.

Aerogen Articles & Posters
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