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Nektar's proprietary micropump technology sets a new performance standard for liquid pulmonary drug delivery by efficiently delivering aerosolized drugs to the lungs, on target, every time. Using an aerosol generator as small as 15 mm in diameter, the micropump technology produces a fine liquid mist of precisely defined particle sizes that can be tailored for respiratory therapy or systemic delivery, and is capable of delivering a broad range of drugs in solution or suspension.

Nektar's proprietary aerosol generator consists of a unique dome-shaped aperture plate containing over 1,000 precision-formed tapered holes, surrounded by a vibrational element. When energy is applied, the aperture plate vibrates over 100,000 times per second. This rapid vibration causes each aperture to act as a micropump, drawing liquid through the holes to form consistently sized droplets. The result is a low-velocity liquid aerosol optimized for maximum lung deposition.

Our proprietary micropump technology aerosolizes efficiently, leaving virtually no residual liquid, and operates without using propellants or generating heat, thereby preserving a drug's molecular integrity. Nektar's proprietary micropump technology works with most pre-existing liquid formulations and can be customized for an individual therapeutic application by adjusting the particle size: a 3-5 micron particle size targets the lungs broadly for respiratory therapy, and a 1-2 micron particle size targets the deep lung for systemic delivery. Combined, these advantages make Nektar's proprietary micropump technology ideal for delivery of a broad range of drugs including small molecules, proteins, peptides and liposome-based therapies.