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The Nektar Pulmonary Drug Delivery System (PDDS) is a proprietary platform for the high-efficiency delivery of aerosolized drugs to patients, particularly those requiring positive-pressure breathing assistance, including mechanical ventilation. The Nektar PDDS is designed to provide exceptionally high deposition of drug directly to the lung, providing a several fold increase in the delivered lung dose as compared to current methods of aerosolized medication delivery¹. Unlike nebulizers and inhalers, the Nektar PDDS is designed to deliver reproducible and consistent doses across a wide range of ventilator settings for any patient population, including neonates.

The Nektar PDDS includes a software driven controller capable of sensing ventilator performance parameters and aerosolizing drug during a predetermined portion of the ventilator cycle. An Aerosol Generator with a pre-set particle size is used to customize the particle size for each individual therapeutic application and the selected drug. The aerosol generator can be placed in-line in an optimal position with the ventilator circuit, and is powered by the controller to produce aerosol only during the appropriate portion of the patient’s inspiration.

(ref 1 Mercier, E., Valat, C., Fishman, R.S., et al. Aerosol delivery of amikacin by three nebulizers of varying efficiency in patients on mechanical ventilators. Poster presentation, American Thoracic Society Conference, Orlando, Florida. May 2004.)