NKTR-255 is an investigational IL‐15 receptor agonist designed to boost the immune system’s natural ability to fight cancer. NKTR-255 increases the proliferation and survival of cancer-killing natural killer (NK) cells and memory CD8+ T cells. NKTR-255 engages the entire IL-15 receptor complex (IL‐15Rα/IL‐15Rβγ) to enhance the formation of long-term immunological memory, which may lead to sustained antitumor immune response.

NKTR-255 is specifically engineered using Nektar’s expertise in polymer chemistry to mimic the natural biological activity of the body’s own IL-15, resulting in optimal activation of the IL-15 pathway. NKTR-255 is uniquely designed to overcome the challenges of recombinant IL-15, which has to be given in high doses due to rapid clearance from the body, limiting its utility due to toxicity and lack of convenience and use.

NKTR-255 is currently being evaluated in a Phase 1 study in patients with relapsed/refractory (R/R) non-Hodgkin’s lymphoma (NHL) and R/R multiple myeloma (MM) and a Phase 1b/2 trial in combination with ERBITUX® for the treatment of R/R colorectal cancer (CRC) and R/R squamous cell carcinoma of the head and neck (SCCHN).

2021 Society for Immunotherapy of Cancer (SITC) Annual Meeting

2021 European Society for Medical Oncology (ESMO) Congress

2021 Future Oncology

2021 Journal for ImmunoTherapy of Cancer

62nd American Society of Hematology (ASH) Annual Meeting & Exposition

2020 Society for Immunotherapy of Cancer (SITC) Annual Meeting

61st American Society of Hematology (ASH) Annual Meeting & Exposition, Orlando, FL

2019 Society for Immunotherapy of Cancer (SITC) Annual Meeting

4th Congress of European Hematology Association (EHA)

AACR 2019

2018 ASH 60th Annual Meeting

SITC 2018

2018 American Conference on Pharmacometrics (ACoP), San Diego, CA

CHI 3rd Annual NK Cell-Based Cancer Immunotherapy Conference, Boston, MA

CHI 2nd Annual Emerging Immuno-Oncology Targets Conference, Boston, MA

Society for Immunotherapy in Cancer (SITC) 32nd Annual Meeting, National Harbor, MD

2017 American Association for Cancer Research (AACR) Annual Meeting

2016 SITC Annual Meeting